Authorities say a collision between a Burlington Northern Santa Fe train and a semi carrying anhydrous ammonia injured four people west of Murdock.
Swift County sheriff's officials say it happened Tuesday about 8:30 a-m.
The accident caused a small leak of the chemical and evacuated an elementary school.
A chemical assessment team was called to secure the ammonia leak.
B-N-S-F spokeswoman Amy McBeth says three train crew members suffered non-life-threatening injuries and the driver of the semi was also hurt.
Sheriff's officials say one of the injured was airlifted from the scene.
Students from Murdock Elementary were moved to Kerkhoven High School.
McBeth says none of the cars of the train, headed for Kansas City, Missouri derailed.